Biphasic change in human peripheral vascular resistance produced by carnigen.

IWATSUKI, N. AMAHA, K. and KoGA, Y. Biphasic Change in Human Peripheral Vascular Resistance Produced by Carnigen®. Tohoku J. exp. Med., 1982, 138 (1), 81-85 The response of the human peripheral vascularesistance (TPR) to carnigen® was examined on 11 patients by measuring arterial pressure change during cardiopulmonary bypass at a constant pump flow. The administration of 2 ml of carnigen into the bypass for the adult and 1 ml for the child produced an initial transient (36 sec) decrease in arterial pressure (9%) followed by a definite increase (13% at 5 min after administration). The present results, therefore, reveal that carnigen possesses a property changinghuman TPR in bphasic mode; a transient decrease at first followed by a definite increase. --vasopressor; carnigen®; peripheral vascular esistance; cardiopulmonary bypass